1-(4-bromophenyl)-5-methyl-1,2,3-triazole synthesis

2synthesis methods

Product Name:1-(4-bromophenyl)-5-methyl-1,2,3-triazole
CAS Number:20177-64-4
Molecular formula:C9H8BrN3
Molecular Weight:238.08

In a round bottom flask, 4-bromophenyl azide (0.1 mmol) and Tetramethylguanidine (0.3 mmol) were further added. Then dimethyl acetonylphosphonate (0.1 mmol) was added. After stirring at 80 for 16h, the entire reaction was monitored by TLC until the reaction was completed. Finally, the crude product is extracted with water and ethyl acetate, dried over anhydrous magnesium sulfate, and then separated by silica gel column to obtain pure product 1-(4-bromophenyl)-5-methyl-1,2,3-triazole.

1-(4-bromophenyl)-5-methyl-1,2,3-triazole

4202-14-6 Synthesis

4202-14-6
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2101-88-4
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$65.00/100mg

20177-64-4
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Yield:20177-64-4 91%

Reaction Conditions:

with N,N,N',N'-tetramethylguanidine in acetonitrile at 80; for 16 h;

Steps:

2 Example 2

In a round bottom flask, 4-bromophenyl azide (0.1 mmol)Tetramethylguanidine (0.3 mmol) was further added,Stir wellThen further dimethyl acetonylphosphonate (0.1 mmol) was added,After stirring at 80 for 16h,The entire reaction was monitored by TLC until the reaction was completed.Finally, the crude product is extracted with water and ethyl acetate,Dried over anhydrous magnesium sulfate,Then separated by silica gel column to obtain pure product,The yield is 91%

References:

CN105949136,2016,A Location in patent:Paragraph 0008; 0012

20725-34-2 Synthesis

1-(4-bromophenyl)-5-methyl-1H-1,2,3-triazole-4-carboxylic acid

20725-34-2
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$44.00/100mg

20177-64-4
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References