1-(4-Bromophenyl)cyclopentanamine HCl synthesis
1synthesis methods
- Product Name:1-(4-Bromophenyl)cyclopentanamine HCl
- CAS Number:1172462-36-0
- Molecular formula:C11H15BrClN
- Molecular Weight:276.6005
Yield:1172462-36-0 28%
Reaction Conditions:
Stage #1: 4-bromobenzenecarbonitrile;1,4-bis(bromomagnesium)butane in diethyl ether at 20; for 0.5 h;
Stage #2: with titanium(IV)isopropoxide in diethyl ether at 20; for 24 h;Further stages;
References:
Tomashenko, Olesya A.;Rudenko, Andrei E.;Sokolov, Viktor V.;Tomashevskiy, Alexander A.;De Meijere, Armin [European Journal of Organic Chemistry,2010,# 8,p. 1574 - 1578] Location in patent:experimental part