1-(4-CHLOROBENZYL)-1H-INDOLE-2-CARBOXYLIC ACID synthesis
- Product Name:1-(4-CHLOROBENZYL)-1H-INDOLE-2-CARBOXYLIC ACID
- CAS Number:220677-67-8
- Molecular formula:C16H12ClNO2
- Molecular Weight:285.73
199604-34-7
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220677-67-8
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Yield:220677-67-8 99%
Reaction Conditions:
with potassium hydroxide in ethanol at 20; for 24 h;
Steps:
4.2.3 Alkaline hydrolysis
General procedure: To a solution of ethyl ester (2mmol) in ethanol was added 1M KOH (4mL) and the mixture stirred for 24h at room temperature. Upon completion of the reaction which was monitored by TLC, the ethanol was evaporated from the mixture and the remaining water phase acidified with 1M HCl to pH ～3. The obtained precipitate was filtered off and dried at 75°C in an oven to afford compounds.
References:
Ke?ek Ple?ec, Kaja;Urban?i?, Dunja;Gobec, Martina;Peko?ak, Aleksandra;Toma?i?, Tihomir;Anderluh, Marko;Mlinari?-Ra??an, Irena;Jakopin, ?iga [Bioorganic and Medicinal Chemistry,2016,vol. 24,# 21,p. 5221 - 5234]
3770-50-1
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220677-67-8
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$184.00/500mg
622-95-7
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220677-67-8
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$184.00/500mg
1202-04-6
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220677-67-8
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$184.00/500mg
104-83-6
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220677-67-8
7 suppliers
$184.00/500mg