1-(4-chloropyridin-2-yl)propan-1-one synthesis
- Product Name:1-(4-chloropyridin-2-yl)propan-1-one
- CAS Number:896139-36-9
- Molecular formula:C8H8ClNO
- Molecular Weight:169.61
19235-89-3
257 suppliers
$10.00/1g
925-90-6
345 suppliers
$12.00/5ml
896139-36-9
32 suppliers
$45.00/10mg
Yield:896139-36-9 86%
Reaction Conditions:
Stage #1: 4-chloro-pyridine-2-carbonitrile;ethylmagnesium bromide in tetrahydrofuran;diethyl ether at -15 - 20; for 5 h;Inert atmosphere;
Stage #2: with hydrogenchloride in tetrahydrofuran;water;ethylene glycol at 20; for 0.5 h;Inert atmosphere;Schlenk technique;
References:
Li, Xuezhao;Wu, Jinguo;Chen, Liyong;Zhong, Xiaoming;He, Cheng;Zhang, Rong;Duan, Chunying [Chemical Communications,2016,vol. 52,# 62,p. 9628 - 9631] Location in patent:supporting information
1121-76-2
200 suppliers
$8.00/1g
896139-36-9
32 suppliers
$45.00/10mg