![](/CAS/GIF/727733-92-8.gif)
1-(4-CYANOBENZYL)PIPERIDINE synthesis
- Product Name:1-(4-CYANOBENZYL)PIPERIDINE
- CAS Number:727733-92-8
- Molecular formula:C13H16N2
- Molecular Weight:200.28
Yield:727733-92-8 98%
Reaction Conditions:
with potassium hydroxide in water at 50; for 3 h;Green chemistry;
Steps:
4.2.1 General procedure for the reactions between (pseudo)halides 1 and formamides 2
General procedure: KOH (2.4mmol), H2O (1.0mL), (pseudo)halides 1 (0.8mmol), and formamides 2 (1.6mmol) were successively added into a reaction tube. Then the reaction mixture was stirred under the conditions shown in Tables 1-5. After the reactions were completed, the mixture was extracted by ethyl acetate, dried over anhydrous Na2SO4, filtered, concentrated under reduced pressure, and purified by flash chromatography to give products 3.
References:
Chen, Wen-Xin;Zhang, Cai-Yun;Shao, Li-Xiong [Tetrahedron,2014,vol. 70,# 4,p. 880 - 885]
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