ChemicalBook CAS DataBase List 1,4-di(pyridin-3-yl)benzene

1,4-di(pyridin-3-yl)benzene synthesis

5synthesis methods

Product Name:1,4-di(pyridin-3-yl)benzene
CAS Number:446311-36-0
Molecular formula:C16H12N2
Molecular Weight:232.28

626-55-1 Synthesis

626-55-1
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4612-26-4 Synthesis

4612-26-4
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446311-36-0
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Yield:446311-36-0 86%

Reaction Conditions:

with C₃₇H₄₅ClN₂O₃PPd;potassium carbonate in ethanol;water at 80; for 6 h;Inert atmosphere;Schlenk technique;Suzuki Coupling;

Steps:

General procedure for Suzuki coupling reactions

A 10-mL round-bottom flask was charged with the prescribe damount of catalyst, 1,4-benzenediboronic acid (0.5 mmol), N-heteroaryl halides (1.5 mmol), the selected base (1.5 mmol) and solvent (4 mL). The flask was placed in an oil bath and heated at 80 °C for 6 h, then cooled to room temperature and extracted with CH₂Cl₂. The crude products obtained from evaporation were purified by flash chromatography on silica gel. The products 5b-c, 5f, 5m [21], 5d [22], 5e [23], 5l [24] were known compounds and characterized by the comparison of data with those in the literature. The products 5a, 5g-k, 5n-o were new compounds and characterized by elemental analysis, IR, MS,¹H and ¹³C NMR.

References:

Xiao, Zhi-Qiang;Xu, Chen;Li, Hong-Mei;Han, Xin;Wang, Zhi-Qiang;Fu, Wei-Jun;Hao, Xin-Qi;Song, Mao-Ping [Transition Metal Chemistry,2015,vol. 40,# 5,art. no. 9942,p. 501 - 508]

626-55-1 Synthesis

626-55-1
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99770-93-1 Synthesis