1,4-DIBROMO-2-(CHLOROMETHYL)BENZENE synthesis
- Product Name:1,4-DIBROMO-2-(CHLOROMETHYL)BENZENE
- CAS Number:642091-49-4
- Molecular formula:C7H5Br2Cl
- Molecular Weight:284.38
Yield:642091-49-4 72%
Reaction Conditions:
with sulfuric acid;sodium chloride at 30 - 35; for 40.5 h;Reagent/catalyst;Temperature;
Steps:
1 Example 1: Chloromethylation with Sodium Chloride as Chlorinating Agent
In a 1 L four-necked flask, 800 ml of sulfuric acid (98%) was added, 20 g of paraformaldehyde was slowly added, and the solid was stirred and dissolved completely.40 g of anhydrous sodium chloride was added in portions and the solution was dissolved with stirring.118g of dibromobenzene was added in batches and added within 30 min. The reaction was incubated at 30-35° C. for 40 h.After the TLC reaction was completed, the reaction solution was slowly added to 2.5 L of ice water, extracted with 1 L of dichloromethane, washed once with 500 ml of water, and dried and concentrated on the organic layer with anhydrous sodium sulfate.125g of solid was added to 250ml of ethanol and heated to reflux to dissolve completely. The crystals were naturally crystallized and filtered to obtain white solid 2,5-dibromobenzyl chloride (103g, yield 72%).
References:
CN107759459,2018,A Location in patent:Paragraph 0007; 0008; 0011; 0012; 0013; 0018
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