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137000-66-9

1,4-Diethynyl-2-fluorobenzene synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: diisopropylamine; PPh3 / Pd(OAc)2; CuI / tetrahydrofuran / 8 h / Heating
2: 82 percent / KOH / tetrahydrofuran; methanol / 2 h / 20 °C

References:

Khan, Muhammad S.;Al-Mandhary, Muna R. A.;Al-Suti, Mohammed K.;Corcoran, Timothy C.;Al-Mahrooqi, Yaqoub;Attfield, J. Paul;Feeder, Neil;David, William I. F.;Shankland, Kenneth;Friend, Richard H.;Koehler, Anna;Marseglia, Elisabeth A.;Tedesco, Emilio;Tang, Chiu C.;Raithby, Paul R.;Collings, Jonathan C.;Roscoe, Karl P.;Batsanov, Andrei S.;Stimson, Lorna M.;Marder, Todd B. [New Journal of Chemistry,2003,vol. 27,# 1,p. 140 - 149]