1-(4-Fluoro-2-methoxy-5-nitro-phenyl)-ethanone synthesis

Yield:1033716-79-8 99%

Reaction Conditions:

with sulfuric acid;potassium nitrate at 20; for 3 h;

Steps:

5.1 First step: Preparation of 1-(4-fluoro-2-methoxy-5-nitrophenyl)ethanone

1-(4-Fluoro-2-methoxyphenyl)ethanone (5.5 g, 32.7 mmol) was added to concentrated sulfuric acid (36 mL), cooled to -10 ° C, and potassium nitrate (3.47 g, 34.3 mmol) ),After the addition, the mixture was stirred at room temperature for 3 hours. The reaction solution was slowly added dropwise to ice water.The solid is precipitated, filtered and dried to give the title compound of this step(6.654 g, yield: 99%).

References:

CN109956928,2019,A Location in patent:Paragraph 0204-0207