1-(4-HYDROXYPHENYL)-3-(2-THIENYL)-2-PROPEN-1-ONE synthesis

Yield:224638-42-0 96%

Reaction Conditions:

with potassium hydroxide in ethanol;water at 20;Sonication;Claisen-Schmidt Condensation;

Steps:

3.2.1. Synthesis of 4-Hydroxy-Chalcones (a1-13)

General procedure: A modied Claisen-Schmidt condensation was performed between 4-hydroxy acetophenone and the suitable substituted aryl aldehyde at a molar ratio 1:1 in absolute ethanol (10 mL) [29]. Three milliliters (3 mL) aqueous KOH (20%) was added. The mixture was stirred at room temperature in a US-bath. The end of the reaction was monitored by TLC. The mixture was treated with aqueous HCl 10% and adjusted to acidic pH. The precipitate was either ltered and washed with cold water or extracted with CHCl3 (30 mL × 3). The combined organic layers were washed with water and brine and dried under anhydrous MgSO4. The product was evaporated to dryness and puried by recrystallization from a proper solvent.

References:

Liargkova, Thalia;Eleftheriadis, Nikolaos;Dekker, Frank;Voulgari, Efstathia;Avgoustakis, Constantinos;Sagnou, Marina;Mavroidi, Barbara;Pelecanou, Maria;Hadjipavlou-Litina, Dimitra [Molecules,2019,vol. 24,# 1,art. no. 199]