1-(4-METHYL-1H-IMIDAZOL-2-YL)-ETHANONE synthesis
- Product Name:1-(4-METHYL-1H-IMIDAZOL-2-YL)-ETHANONE
- CAS Number:2524-90-5
- Molecular formula:C6H8N2O
- Molecular Weight:124.14
78-98-8
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2524-90-5
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Yield:2524-90-5 11%
Reaction Conditions:
with ammonium acetate in acetic acid at 100;
Steps:
Compound 198.1. l-(4-Methyl-lH-imidazol-2-yl)ethanone
Compound 198.1. l-(4-Methyl-lH-imidazol-2-yl)ethanone.
Into a 500-mL round- bottom flask, was placed an aqueous solution of 2-oxopropanal (25.2 mL, 222.0 mmol, 50%). Ammonium acetate (85 g, 1.10 mol) and acetic acid (200 mL) were added to the reaction. The reaction mixture was stirred overnight at 100 °C, then concentrated under reduced pressure. The residue was diluted with 300 mL of EtOAc. The organic layer was washed with 4 x 30 mL of brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by a silica gel chromatography with ethyl acetate/hexane (1 : 1) as %) of the title compound as a yellow solid.
References:
WO2015/95767,2015,A1 Location in patent:Page/Page column 240
127-19-5
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111539-75-4
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2524-90-5
29 suppliers
$99.00/250mg