1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE synthesis
- Product Name:1-(4-METHYL-2-(METHYLAMINO)THIAZOL-5-YL)ETHANONE
- CAS Number:94284-66-9
- Molecular formula:C7H10N2OS
- Molecular Weight:170.23
598-52-7
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94284-66-9
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$56.00/100mg
Yield:94284-66-9 98%
Reaction Conditions:
with pyridine at 20; for 4 h;
Steps:
12 1-[4-Methyl-2-(methylamino)thiazol-5-yl]ethanone
Add N-methylthiourea (1.00g, 11.09mmol), 3-chloro-2,4-pentanedione (1.32mL, 11.09mmol) and pyridine (1.07mL, 13.31mmol) in a 100mL eggplant-shaped flask, methanol 30mL was dissolved, stirred at room temperature for 4h, TLC detected the raw material point disappeared, the excess solvent was evaporated under reduced pressure,50mLsaturated NaHCO3solution wasadded, a white precipitate was precipitated, and a white solid 1.86g was obtained by suction filtration with a yield of 98%;
References:
CN112010844,2020,A Location in patent:Paragraph 0297; 0300-0302