1-(4-Methyloxazol-5-yl)ethanone synthesis
- Product Name:1-(4-Methyloxazol-5-yl)ethanone
- CAS Number:23012-19-3
- Molecular formula:C6H7NO2
- Molecular Weight:125.13
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Yield:-
Reaction Conditions:
with formic acid;formamide in water;
Steps:
20 Preparation of 5-Acetyl-4-methyloxazole
EXAMPLE 20 Preparation of 5-Acetyl-4-methyloxazole A mixture of 3-chloro-2,4-pentanedione (26.8 g), formamide (18.0 g), and formic acid (50.0 g) was heated in a 140° C. oil bath and refluxed for 4 hours. The resulting dark mixture was poured into 100 ml of water, basified with 50% NaOH solution, and saturated with NaCl. The mixture was extracted with ethyl ether (3*100 ml). The ether solution was dried over sodium sulfate and concentrated. The residue was vacuum-distilled to yield 6.59 g of 5-acetyl-4-methyloxazole as a colorless liquid, 84° C. (15 torr). NMR: 2.51 (s, 3H), 2.52 (s, 3H), 7.85 (s, 1H).
References:
US5470862,1995,A
