ChemicalBook CAS DataBase List 1-(4-Trifluoromethyl-thiazol-2-yl)-piperazine

1-(4-Trifluoromethyl-thiazol-2-yl)-piperazine synthesis

2synthesis methods

Product Name:1-(4-Trifluoromethyl-thiazol-2-yl)-piperazine
CAS Number:107507-53-9
Molecular formula:C8H10F3N3S
Molecular Weight:237.25

4-(4-TRIFLUOROMETHYL-THIAZOL-2-YL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

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1-(4-Trifluoromethyl-thiazol-2-yl)-piperazine

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Yield:-

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 20; for 2 h;

Steps:

53.2

The intermediate from step 1 (0.5 g) was stirred in a mixture of TFA (10 mL) and CH₂Cl₂(40 mL) at room temperature for 2 hours, then concentrated. To remove remaining TFA, the residue was re-dissolved in CH₂Cl₂(50 mL) and concentrated again to give 0.3 g of intermediate 1-(4-Trifluoromethyl-thiazol-2-yl)-piperazine as a light yellow oil.

References:

US2005/234046,2005,A1 Location in patent:Page/Page column 61

110-85-0 Synthesis

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228119-52-6 Synthesis

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References