ChemicalBook CAS DataBase List 1-(5-AMino-2-broMophenyl)ethanone

1-(5-AMino-2-broMophenyl)ethanone synthesis

5synthesis methods

Product Name:1-(5-AMino-2-broMophenyl)ethanone
CAS Number:149914-98-7
Molecular formula:C8H8BrNO
Molecular Weight:214.06

99-03-6 Synthesis

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Yield:149914-98-7 94.71%

Reaction Conditions:

with N-Bromosuccinimide in d₇-N,N-dimethylformamide at 25; for 2 h;

Steps:

24.1 24.1 Preparation of 1-(5-amino-2-bromo-phenyl)ethanone

A solution of 1-(3-aminophenyl)ethanone (10.0 g, 74.0 mmol, 1 eq) in DMF (70 mL) was dropwise a solution of NBS (13.2 g, 74.0 mmol, 1 eq) in DMF (70 mL) at 25°C over a period of 1 h, the resulting mixture was stirred at 25°C for 1 h. The reaction mixture was poured into H₂O (100 mL), and the aqueous phase was extracted with EtOAc (40 mL x 3). The combined organic layers were washed with sat. aq. NaHCO₃ (20 mL x 3), H₂O (15 mL x 3) and brine (10 mL x 3), dried over Na₂SO₄, filtered and concentrated in vacuo to give 1-(5-amino-2-bromo- phenyl)ethanone (15.0 g, 70.1 mmol, 94.71% yield) was as brown oil.¹H NMR (CDCl₃, 400 MHz) d 7.34 (d, J = 8.4 Hz, 1H), 6.75 (d, J = 2.8 Hz, 1H), 6.62 (dd, J = 8.8, 2.8 Hz, 1H), 3.82 (br s, 2H).

References:

WO2021/3501,2021,A1 Location in patent:Paragraph 0394-0396

99-03-6 Synthesis

99-03-6
394 suppliers
$6.00/10g