1-(5-bromo-3-pyridinyl)-1-propanone synthesis

5synthesis methods

Product Name:1-(5-bromo-3-pyridinyl)-1-propanone
CAS Number:341555-43-9
Molecular formula:C8H8BrNO
Molecular Weight:214.06

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Yield:341555-43-9 88%

Reaction Conditions:

in tetrahydrofuran at 10; for 4 h;

Steps:

1.1 1. Synthesis of (5-bromopyridin-3-yl) ethyl ketone

20.8 g of N-methyl-N-methoxy-5-bromo-nicotinamide was dissolved in 200 ml of tetrahydrofuran, cooled to 10 degrees, and 45 ml of a 2 M solution of ethylmagnesium chloride in tetrahydrofuran was added.After the reaction was continued for 4 hours, it was warmed to room temperature and quenched with water.It was extracted twice with ethyl acetate and the organic phase was desolvated. Distillation under reduced pressure gave 16 g of a pale yellow solid with a yield of 88%.

References:

CN107954927,2018,A Location in patent:Paragraph 0016