1-(5-bromopyridin-2-yl)azetidin-3-ol synthesis
- Product Name:1-(5-bromopyridin-2-yl)azetidin-3-ol
- CAS Number:1339319-85-5
- Molecular formula:C8H9BrN2O
- Molecular Weight:229.07
53939-30-3
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Yield:1339319-85-5 5.8%
Steps:
3.4.4 5.4.4.
5.4.4.
Synthesis of 1-(5-bromopyridin-2-yl)azetidin-3-ol
To a mixture of azetidin-3-ol hydrochloride (3.3 g, 45.15 mmol) and 5-bromo-2-chloro-pyridine (8.69 g, 45.15 mmol) in DMF (50 mL) was added K2CO3 (18.72 g, 135.44 mmol), the reaction mixture was stirred at 120° C. for 3 h.
The mixture was poured into water (500 mL), extracted with EA (100 mL*3).
The organic was washed by brine (300 mL), then dried over Na2SO4 and concentrated.
The residue was purified by column chromatography to afford 1-(5-bromopyridin-2-yl)azetidin-3-ol (600 mg, 5.80% yield) as a yellow solid. MS: m/z=229.0 (M+1, ESI+).
References:
US2022/106311,2022,A1