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1-(5-Hydroxy-2-Methylphenyl)ethanone synthesis

5synthesis methods
Preparation from 5-acetyl-4-methyl-3-cyclohexenone by aromatization promoted, ? by cupric bromide with lithium bromide in refluxing acetonitrile (80%) ; ? by 10% Pd/C in refluxing xylene (50%).
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Yield:40180-70-9 68%

Reaction Conditions:

in tetrahydrofuran;diethyl ether at -78 - 25; for 17 h;Inert atmosphere;

References:

Lafleur, Karine;Huang, Danzhi;Zhou, Ting;Caflisch, Amedeo;Nevado, Cristina [Journal of Medicinal Chemistry,2009,vol. 52,# 20,p. 6433 - 6446] Location in patent:experimental part