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1,5-Naphthyridin-4-amine,6-methoxy-(9CI) synthesis
- Product Name:1,5-Naphthyridin-4-amine,6-methoxy-(9CI)
- CAS Number:249889-69-8
- Molecular formula:C9H9N3O
- Molecular Weight:175.19
![Methanesulfonic acid, 1,1,1-trifluoro-, 6-methoxy-1,5-naphthyridin-4-yl ester](/CAS/20200331/GIF/394223-86-0.gif)
394223-86-0
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249889-69-8
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Yield:249889-69-8 63%
Reaction Conditions:
with pyridine;1-aminopropane hydrochloride for 4 h;Heating / reflux;
Steps:
1.c
A solution of triflate (lb) (8. 0g) and propylamine hydrochloride (15. 8g) in pyridine (120mL) was heated at reflux for 4 hours. The solvent was evaporated and the mixture dissolved in 0. 05M hydrochloric acid (600mL) and washed with dichloromethane. The mixture was basified with 40% sodium hydroxide and extracted with dichloromethane. The extracts were dried, evaporated and chromatographed on silica gel (2-5% methanol in dichloromethane) to give an orange solid (3.6g, 63%). 8H (CDC13, 250MHz), 8.39 (1H, d, ), 8.09 (1H, d,), 7.08 (1H, d, ), 6.71 (1H, d, ), 5.25 (2H, brs), 4.05 (3H, s). MS (+ve ion electrospray) m/z: 176 (MH+).
References:
WO2003/87098,2003,A1 Location in patent:Page/Page column 37