ChemicalBook CAS DataBase List 1,6-DIBROMO-2-HYDROXYNAPHTHALENE-3-CARBOXYLIC ACID

1,6-DIBROMO-2-HYDROXYNAPHTHALENE-3-CARBOXYLIC ACID synthesis

6synthesis methods

Product Name:1,6-DIBROMO-2-HYDROXYNAPHTHALENE-3-CARBOXYLIC ACID
CAS Number:1779-10-8
Molecular formula:C11H6Br2O3
Molecular Weight:345.97

92-70-6 Synthesis

92-70-6
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1,6-DIBROMO-2-HYDROXYNAPHTHALENE-3-CARBOXYLIC ACID

1779-10-8
108 suppliers
$14.00/5g

Yield: 91%

Reaction Conditions:

with bromine;acetic acid at 120; for 3 h;

Steps:

1.1 step 1:
1L three-necked flask,3-hydroxy-2-naphthoic acid (50 g, 0.27 mol)And 600 mL of glacial acetic acid, stirred and dissolved.Bromine (34 mL, 0.67 mol) was treated with 100 mLGlacial acetic acid diluted, slowly dropping into the reaction solution,Keep the temperature 20-30 ° C.After completion of the dropwise addition, the temperature was raised to 120 ° C,Reflux 3h. Stop heating,Naturally cooled to room temperature,The reaction solution was poured into 3000 mL of ice water,Precipitation of a large number of yellow solid,Filter, filter cake with water,Oven drying,To give 84 g of intermediate 2 as a solid, 91% yield.

References:

The Chinese People's Liberation Army Military Academy Of Medical Sciences Poison Pharmaceutical Institute;Zhong Wu;Li Song;Qiao Changjiang;Zhu Dianxi CN106866433, 2017, A Location in patent:Paragraph 0075; 0076; 0077