[1-(6-methoxy-2-naphthyl)ethyl]amine hydrochloride synthesis
- Product Name:[1-(6-methoxy-2-naphthyl)ethyl]amine hydrochloride
- CAS Number:51872-03-8
- Molecular formula:C13H16ClNO
- Molecular Weight:237.73
3900-45-6
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Yield:51872-03-8 85%
Reaction Conditions:
Stage #1: 6-methoxy-2-acetylnaphthalenewith titanium(IV) isopropylate;ammonia in ethanol; for 0.25 h;Inert atmosphere;
Stage #2: with sodium tetrahydroborate in ethanol at 20; for 3 h;
Stage #3: with hydrogenchloride in tert-butyl methyl ether;
References:
Scheidt, Thomas;Land, Henrik;Anderson, Mattias;Chen, Yujie;Berglund, Per;Yi, Dong;Fessner, Wolf-Dieter [Advanced Synthesis and Catalysis,2015,vol. 357,# 8,p. 1721 - 1731]