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1-(6-(pyrrolidin-1-yl)pyridin-3-yl)ethanone synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: dimethyl malonate; MgCl2; Et3N
1.2: H2O
2.1: ethanol

References:

Zheng, Guo Zhu;Lee, Chih-Hung;Pratt, John K.;Perner, Richard J.;Jiang, Mei Qun;Gomtsyan, Arthur;Matulenko, Mark A.;Mao, Yui;Koenig, John R.;Kim, Ki H.;Muchmore, Steve;Yu, Haixia;Kohlhaas, Kathy;Alexander, Karen M.;McGaraughty, Steve;Chu, Katharine L.;Wismer, Carol T.;Mikusa, Joseph;Jarvis, Michael F.;Marsh, Kennan;Kowaluk, Elizabeth A.;Bhagwat, Shripad S.;Stewart, Andrew O. [Bioorganic and Medicinal Chemistry Letters,2001,vol. 11,# 16,p. 2071 - 2074]