1-(7-chloronaphthalen-1-yl)ethanone synthesis

6synthesis methods

Product Name:1-(7-chloronaphthalen-1-yl)ethanone
CAS Number:58149-93-2
Molecular formula:C12H9ClO
Molecular Weight:204.65

91-58-7 Synthesis

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Yield:58149-93-2 91.8%

Reaction Conditions:

Stage #1: 2-chloronaphthalenewith aluminum (III) chloride in dichloromethane at 0; for 2 h;Inert atmosphere;
Stage #2: acetyl chloride in dichloromethane at 3; for 2 h;Temperature;

Steps:

1.1; 2.1

Put 9g of compound A and 20mL of dichloromethane into the reactor under nitrogen protection, Cool to 0°C, add 6g aluminum trichloride, stir for 2h, adjust the temperature to 3°C, add 18g acetyl chloride, keep the reaction for 2h, TLC test, the raw material reaction is complete, pour the reaction solution into ice water (200mL), concentrated hydrochloric acid Adjust the pH to 3, extract with dichloromethane (200mL*2), concentrate, Add 20mL ethanol to the concentrate, stir for 10 minutes, filter, and dry the filter cake. Obtain 10.4 g of white solid to obtain compound B with a yield of 91.8% and a purity of 97.8%;

References:

CN112125790,2020,A Location in patent:Paragraph 0012; 0014

91-58-7 Synthesis

91-58-7
159 suppliers
$37.00/1G

75-36-5 Synthesis

75-36-5
566 suppliers
$17.92/100G

58149-93-2
6 suppliers
inquiry