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1,7-Dimethyl-1H-benzo[d]imidazol-2-amine synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 4 steps
1: copper / water / 8 h / 100 °C / Sealed tube
2: hydrogen / ethanol / 3 h / 20 °C / 760.05 Torr
3: toluene-4-sulfonic acid / isopropyl alcohol / 16 h / 65 °C
4: hydrogenchloride / 1,4-dioxane / 0.5 h / 100 °C

References:

Windisch, Marc Peter;Jo, Suyeon;Kim, Hee-Young;Kim, Soo-Hyun;Kim, Keumhyun;Kong, Sunju;Jeong, Hyangsuk;Ahn, Sujin;No, Zaesung;Hwang, Jong Yeon [European Journal of Medicinal Chemistry,2014,vol. 78,p. 35 - 42]