1,7-Naphthyridin-8(7H)-one, 5-bromo-3-chloro- synthesis

4synthesis methods

Product Name:1,7-Naphthyridin-8(7H)-one, 5-bromo-3-chloro-
CAS Number:1600512-90-0
Molecular formula:C8H4BrClN2O
Molecular Weight:259.49

1393575-76-2 Synthesis

1393575-76-2
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1,7-Naphthyridin-8(7H)-one, 5-bromo-3-chloro-

1600512-90-0
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Yield:1600512-90-0 95%

Reaction Conditions:

with N-Bromosuccinimide in water;N,N-dimethyl-formamide;

Steps:

188.1 Step 1

Step 1
A suspension of 3-chloro-1,7-naphthyridin-8(7H)-one (1.6 g, 8.86 mmol) and N-bromosuccinimide (1.892 g, 10.63 mmol) in 8 mL of DMF was stirred at rt.
After 5 h, the reaction was treated with water.
The solid precipitate was filtered, washed with water and ether, air-dried to give 5-bromo-3-chloro-1,7-naphthyridin-8(7H)-one (2.18 g, 8.40 mmol, 95% yield) as an off-white solid.

References:

US2014/107109,2014,A1 Location in patent:Page/Page column

760207-83-8
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1600512-90-0
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References

2-Pyridinecarbonitrile, 5-chloro-3-[2-(trimethylsilyl)ethynyl]-

1600511-73-6
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1600512-90-0
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References

2-Pyridinecarbonitrile, 5-chloro-3-(2,2-dimethoxyethyl)-

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1600512-90-0
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References