1,8-Diazaspiro[4.5]decan-2-one hydrochloride synthesis

Yield:1389313-57-8 100%

Reaction Conditions:

with hydrogenchloride in 1,4-dioxane at 50; for 2 h;Inert atmosphere;

References:

Li, Zhihong;Wang, Xianghong;Eksterowicz, John;Gribble, Michael W.;Alba, Grace Q.;Ayres, Merrill;Carlson, Timothy J.;Chen, Ada;Chen, Xiaoqi;Cho, Robert;Connors, Richard V.;Degraffenreid, Michael;Deignan, Jeffrey T.;Duquette, Jason;Fan, Pingchen;Fisher, Benjamin;Fu, Jiasheng;Huard, Justin N.;Kaizerman, Jacob;Keegan, Kathleen S.;Li, Cong;Li, Kexue;Li, Yunxiao;Liang, Lingming;Liu, Wen;Lively, Sarah E.;Lo, Mei-Chu;Ma, Ji;McMinn, Dustin L.;Mihalic, Jeffrey T.;Modi, Kriti;Ngo, Rachel;Pattabiraman, Kanaka;Piper, Derek E.;Queva, Christophe;Ragains, Mark L.;Suchomel, Julia;Thibault, Steve;Walker, Nigel;Wang, Xiaodong;Wang, Zhulun;Wanska, Malgorzata;Wehn, Paul M.;Weidner, Margaret F.;Zhang, Alex J.;Zhao, Xiaoning;Kamb, Alexander;Wickramasinghe, Dineli;Dai, Kang;McGee, Lawrence R.;Medina, Julio C. [Journal of Medicinal Chemistry,2014,vol. 57,# 8,p. 3430 - 3449]