1-(9-anthracenylmethyl)piperazine synthesis

Yield:126257-22-5 93%

Reaction Conditions:

with trifluoroacetic acid in dichloromethane at 20; for 2 h;

Steps:

4 5.1.3. General procedure for the synthesis of N-arylalkylpiperazines 21-26

General procedure: A 1 mmol portion of the suitable N-arylalkyl-piperazine-N-carboxylic acid tert-butyl esters (15-20) was dissolved in 10 mL of anhydrous CH2Cl2 and 2mL of CF3COOH were added. The reaction mixture was stirred for 2 h at room temperature. The solvent was removed under reduced pressure and the residue was washed three times with a saturated solution of NaHCO3. The organic layer was dried with Na2SO4, and the solvent was removed under reduced pressure yielding a substance which was used as such for the next reaction

References:

Dei, Silvia;Coronnello, Marcella;Bartolucci, Gianluca;Manetti, Dina;Romanelli, Maria Novella;Udomtanakunchai, Chatchanok;Salerno, Milena;Teodori, Elisabetta [European Journal of Medicinal Chemistry,2018,vol. 147,p. 7 - 20]