ChemicalBook CAS DataBase List 1,9-BIS-BOC-1,5,9-TRIAZANONANE

1,9-BIS-BOC-1,5,9-TRIAZANONANE synthesis

12synthesis methods

Product Name:1,9-BIS-BOC-1,5,9-TRIAZANONANE
CAS Number:82409-02-7
Molecular formula:C16H33N3O4
Molecular Weight:331.45

56-18-8 Synthesis

56-18-8
130 suppliers
$23.52/25ML

530-62-1 Synthesis

530-62-1
930 suppliers
$6.00/25g

75-65-0 Synthesis

75-65-0
750 suppliers
$10.00/10ml

82409-02-7
50 suppliers
$80.00/50 mg

Yield: 86%

Reaction Conditions:

Stage #1:1,1'-carbonyldiimidazole;tert-butyl alcohol in toluene at 60; for 5 h;Inert atmosphere;
Stage #2:bis(3-aminopropyl)amine in toluene at 120; for 18 h;

Steps:

1.1.i di-tert-Butyl (azanediylbis(propane-3,l-diyl))dicarbamate (1):
1 , 1 '-Carbonyldiimidazole (CDI) (13.60 g, 84 mmol) was suspended in a mixture of toluene (100 ml) and i-butanol (11.91 g, 15ml, 161 mmol) under nitrogen atmosphere and was heated to 60 °C for 5 h. A solution of norspermidine (5.77 g, 6.2 ml 44 mmol) in toluene (60 ml) was added dropwise. The reaction mixture was refluxed at 120 °C for 18 h, then cool and concentrated under vacuum. The resulting liquid was extracted in dichloromethane, washed with distilled water and finally dried over anhydrous Na₂S0₄, filtered and concentrated in vacuo to give di-tert- butyl (azanediylbis(propane-3,l-diyl))dicarbamate as a white powder (12 g, 86%). ¹H NMR (CDC1₃): δ 5.22 (brs, 2H, -NHCO), 3.21-3.10 (m, 4H, -CH2NHCO), 2.63-2.60 (m, 4H, - CH2NH), 1.65-1.59 (m,4H, -CH₂), 1.40 (s 18 H, C(CH₃)₃).

References:

VYOME BIOSCIENCES PVT. LTD.;GHOSH, Sumana;SINHA, Mau;BHATTACHARYYA, Anamika;SADHASIVAM, Suresh;GHOSH, Shamik;SAMANTA, Ritwik;TANDON, Nupur WO2018/42367, 2018, A2 Location in patent:Page/Page column 72-73

56-18-8 Synthesis

56-18-8
130 suppliers
$23.52/25ML