![](/CAS/GIF/129604-54-2.gif)
1-(9H-FLUOREN-9-YL)PIPERAZINE synthesis
- Product Name:1-(9H-FLUOREN-9-YL)PIPERAZINE
- CAS Number:129604-54-2
- Molecular formula:C17H18N2
- Molecular Weight:250.34
![Piperazine](/CAS/GIF/110-85-0.gif)
110-85-0
548 suppliers
$5.00/5G
![9-BROMOFLUORENE](/CAS/GIF/1940-57-4.gif)
1940-57-4
165 suppliers
$15.00/1g
![1-(9H-FLUOREN-9-YL)PIPERAZINE](/CAS/GIF/129604-54-2.gif)
129604-54-2
15 suppliers
$203.00/100mg
Yield:129604-54-2 100%
Reaction Conditions:
with triethylamine in tetrahydrofuran; for 6 h;Reflux;Inert atmosphere;
Steps:
2.1 4.2.1. 1-(9H-Fluoren-9-yl)piperazine (3)
A solution of 9-bromofluorene 2 (8.2 mmol, 2.0 g, 1.0 eq), triethylamine (1.2 mmol, 165 μL, 0.15 eq) and piperazine (61.1 mmol, 5.27 g, 7 eq) in dry THF (50.0 mL) was refluxed under argon for 6 h.
The reaction mixture was then filtered off and the filtrate was concentrated under vacuum pressure.
The resulting crude product was purified by flash chromatography (isocratic 95/5 dichloromethane/methanol) to afford a white powder (2.04 g, 100%). TLC Rf: 0.12 (dichloromethane/methanol 97/3); mp: 133.6 °C; IR (cm-1): 738, 805, 1007, 1138, 1325, 1448, 2831, 2940, 3294. 1H NMR (300 MHz, DMSO-d6) δ (ppm): 2.46 (m, 4H); 2.66 (m, 4H); 4.86 (s, 1H); 7.32 (td, J = 1.5 Hz, 3.5 Hz, 2H); 7.40 (t, J = 7.5 Hz, 2H); 7.63 (d, J = 7.2 Hz, 2H), 7.83 (d, J = 7.5 Hz, 2H).
13C NMR (75 MHz, DMSO-d6) δ (ppm): 46.7 (2 * CH2), 50.4 (2 * CH2), 70.2 (CH), 120.4 (2 * CH), 126.3 (2 * CH), 127.5 (2 * CH), 128.5 (2 * CH), 140.9 (2 * C), 144.4 (2 * C). MS (ESI) m/z: 251.3 [M+H+]. HRMS (ESI): for C17H19N2 [M+H+]: calcd: 251.1551; found: 251.1548.
References:
Chollet, Aurélien;Mori, Giorgia;Menendez, Christophe;Rodriguez, Frédéric;Fabing, Isabelle;Pasca, Maria Rosalia;Madacki, Jan;Korduláková, Jana;Constant, Patricia;Quémard, Anna?k;Bernardes-Génisson, Vania;Lherbet, Christian;Baltas, Michel [European Journal of Medicinal Chemistry,2015,vol. 101,p. 218 - 235]
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1103929-95-8
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inquiry
![1-(9H-FLUOREN-9-YL)PIPERAZINE](/CAS/GIF/129604-54-2.gif)
129604-54-2
15 suppliers
$203.00/100mg
![Piperazine](/CAS/GIF/110-85-0.gif)
110-85-0
548 suppliers
$5.00/5G
![9-CHLOROFLUORENE](/CAS/GIF/6630-65-5.gif)
6630-65-5
34 suppliers
$55.00/100mg
![1-(9H-FLUOREN-9-YL)PIPERAZINE](/CAS/GIF/129604-54-2.gif)
129604-54-2
15 suppliers
$203.00/100mg
![9-Fluorenone](/CAS/GIF/486-25-9.gif)
486-25-9
463 suppliers
$5.00/25g
![1-(9H-FLUOREN-9-YL)PIPERAZINE](/CAS/GIF/129604-54-2.gif)
129604-54-2
15 suppliers
$203.00/100mg
![9-Fluorenol](/CAS/GIF/1689-64-1.gif)
1689-64-1
300 suppliers
$9.00/5g
![1-(9H-FLUOREN-9-YL)PIPERAZINE](/CAS/GIF/129604-54-2.gif)
129604-54-2
15 suppliers
$203.00/100mg