ChemicalBook CAS DataBase List 1-ACETYL-1H-BENZOTRIAZOLE

1-ACETYL-1H-BENZOTRIAZOLE synthesis

12synthesis methods

Product Name:1-ACETYL-1H-BENZOTRIAZOLE
CAS Number:18773-93-8
Molecular formula:C8H7N3O
Molecular Weight:161.16

95-14-7 Synthesis

95-14-7
853 suppliers
$6.00/100g

75-36-5 Synthesis

75-36-5
561 suppliers
$17.92/100G

18773-93-8
39 suppliers
$18.00/1g

Yield:18773-93-8 100%

Reaction Conditions:

with triethylamine in dichloromethane at 20; for 0.5 h;Cooling;

Steps:

1 Preparation of compound 2.

Benzotriazole (6.52 g, 54.2 mmol) was dissolved in 50 mL anhydrous methylene chloride, under cooling, added first with mol equivalents of triethylamine (11.06 g, 109.5 mmol) then carefully with 1.1 mol equivalents of acetyl chloride (4.7 g, 60.25 mmol) and stirred for 30 min at room temperature. After the reaction was completed, the mixture was diluted with 50 mL 2 N hydrochloric acid and extracted twice with 25 mL methylene chloride. The combined organic phases were washed twice with 20 mL 2 N hydrochloric acid, twice with 20 mL water and then once with 20 mL saturated sodium chloride solution, dried over sodium sulfate and the solvent was removed. The organic phase was dried over Na₂SC>₄, then the solvent was removed under reduced pressure to afford compound 2 in quantitative yield. The compound was pure enough to be used for the following step without further treatment. NMR (600 Hz, CDCh): d (ppm) 8.22-7.93 (m, 2H), 8.02- 7.93(m, lH), 2.53 (s, 3H); ¹³C NMR (150 Hz, CDCh): 171.1, 145.7, 133.4, 128.2, 115.1, 125.5, 121.3, 23.3; ESI-MS (M+H)⁺ 162.27.

References:

WO2020/10021,2020,A1 Location in patent:Page/Page column 26; 27

34801-09-7 Synthesis