ChemicalBook CAS DataBase List 1-acetyl-6-bromo-1,2,3,4-tetrahydroquinoline

1-acetyl-6-bromo-1,2,3,4-tetrahydroquinoline synthesis

4synthesis methods

Product Name:1-acetyl-6-bromo-1,2,3,4-tetrahydroquinoline
CAS Number:22190-40-5
Molecular formula:C11H12BrNO
Molecular Weight:254.12

4169-19-1
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$60.00/500mg

1-acetyl-6-bromo-1,2,3,4-tetrahydroquinoline

22190-40-5
46 suppliers
$36.00/250mg

Yield:22190-40-5 96%

Reaction Conditions:

with N-Bromosuccinimide in DMF (N,N-dimethyl-formamide) at 20; for 3 h;

Steps:

Crude 1- (3, 4-dihydro-2H-quinolin-1-yl)-ethanone was dissolved in DMF (60 mL), and N-bromo succinimide (100 mmol) was added portion wise. Stirred at room temperature for 3h, then the reaction mixture was poured into water (150 mL) and extracted with ethyl acetate. The organic phase was washed with NH4C1 (sat. ), dried over MgS04, filtered and evaporated. Yield: 96% 1H NMR (D6-DMSO) : 1.85 (m, 2H); 2.16 (s, 3H); 2.70 (m, 2H); 3.66 (m, 2H); 7.25- 7.60 (3H).

References:

WO2005/39572,2005,A1 Location in patent:Page/Page column 31

22190-35-8 Synthesis