1-allyl-3-(4-Morpholinophenyl)thiourea synthesis
- Product Name:1-allyl-3-(4-Morpholinophenyl)thiourea
- CAS Number:19318-84-4
- Molecular formula:C14H19N3OS
- Molecular Weight:277.39
51317-66-9
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107-11-9
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19318-84-4
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Yield:19318-84-4 4 g
Reaction Conditions:
in tetrahydrofuran;water at 0 - 10;
Steps:
General Procedure for the Synthesis of Compounds 13-26.
General procedure: A solution of the arylamine derivative in THF was added to saturated NaHCO3 aqueous solution. Then a solution of CSCl2 in THF was added dropwise and the resulting mixture was stirred at 23 °C for 2 h, TLC showed that there was no starting material left. To the above solution, the amine derivative was added dropwise at 0-10 °C. When TLC indicated that the reaction was complete, the solution was extracted with MTBE three times and the organic phase was dried over anhydrous Na2SO4, filtered and evaporated to dryness to produce a crude product. After re-crystallizationin MTBE, a pure product was obtained.
References:
Luo, Rusong;Laitinen, Tuomo;Teng, Liyan;Nevalainen, Tapio;Lahtela-Kakkonen, Maija;Zheng, Baofu;Wang, Honghai;Poso, Antti;Zhang, Xuelian [Letters in drug design and discovery,2013,vol. 10,# 7,p. 640 - 650]
2524-67-6
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19318-84-4
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