1-allyl-4-bromo-2-methylbenzene synthesis
- Product Name:1-allyl-4-bromo-2-methylbenzene
- CAS Number:1037088-26-8
- Molecular formula:C10H11Br
- Molecular Weight:211.1
116632-39-4
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Yield:1037088-26-8 100%
Reaction Conditions:
Stage #1: 2-methyl-4-bromoiodobenzenewith isopropylmagnesium chloride in tetrahydrofuran at -20; for 0.75 h;
Stage #2: with copper(l) iodide;lithium chloride in tetrahydrofuran at -10; for 0.166667 h;
Stage #3: allyl bromide in tetrahydrofuran at -10; for 0.166667 h;Reagent/catalyst;
References:
Glunz, Peter W.;Mueller, Luciano;Cheney, Daniel L.;Ladziata, Vladimir;Zou, Yan;Wurtz, Nicholas R.;Wei, Anzhi;Wong, Pancras C.;Wexler, Ruth R.;Priestley, E. Scott [Journal of Medicinal Chemistry,2016,vol. 59,# 8,p. 4007 - 4018]