ChemicalBook CAS DataBase List 1-amino-2-butyne hydrochloride

1-amino-2-butyne hydrochloride synthesis

3synthesis methods

Product Name:1-amino-2-butyne hydrochloride
CAS Number:50329-23-2
Molecular formula:C4H8ClN
Molecular Weight:105.566

The bis(cyclopentadiene) zirconium dihydride (0.01mmol, 2.23mg), But-2-ynamide (0.2mmol, 16.6mg), and pinacol borane (0.6mmol, 87μL) were added and stirred for 24h at room temperature under nitrogen (1atm) atmosphere, treated with hydrogen chloride in ether solution to obtain the hydrochloride compound (white solid, 1-amino-2-butyne hydrochloride ). The isolated yield was 73%.

6052-32-0
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50329-23-2
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Yield:50329-23-2 73%

Reaction Conditions:

Stage #1: tetrolic acide amidewith bis(cyclopentadienyl)dihydrozirconium;4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane at 20; under 760.051 Torr; for 24 h;Inert atmosphere;
Stage #2: with hydrogenchloride in diethyl ether;Inert atmosphere;

Steps:

84

The bis(cyclopentadiene) zirconium dihydride (denoted as Cp2ZrH2, 0.01mmol, 2.23mg), but-2-ynamide (denoted as 5t, 0.2mmol, 16.6mg) and pinacol borane (denoted as HBpin , 0.6mmol, 87μL), stirred for 24h at room temperature under nitrogen (1atm) atmosphere, treated with hydrogen chloride in ether solution to obtain the hydrochloride compound of formula 6t structure (white solid, but-2-yn-1-amine hydrochloride ). The isolated yield was 73%.

References:

CN112299938,2021,A Location in patent:Paragraph 0262-0264

764-01-2 Synthesis

764-01-2
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50329-23-2
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References

113439-83-1 Synthesis

113439-83-1
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$47.60/5g

50329-23-2
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References