ChemicalBook CAS DataBase List 1-BENZOFURAN-5-YLMETHYLAMINE

1-BENZOFURAN-5-YLMETHYLAMINE synthesis

3synthesis methods

Product Name:1-BENZOFURAN-5-YLMETHYLAMINE
CAS Number:37798-08-6
Molecular formula:C9H9NO
Molecular Weight:147.17

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

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Yield: 54%

Reaction Conditions:

with hydrogen;nickel in tetrahydrofuran

Steps:

E
5-Azidomethyl-benzofuran was hydrogenated with Raney Nickel in tetrahydrofuran. The solution was concentrated under reduced pressure to a yellow oil. The oil was dissolved in ethyl acetate (50 mL), extracted with 1N hydrochloric acid (3×50 mL), pH adjusted to 10 with 1N sodium hydroxide, extracted with ethyl acetate (3×50 mL), dried with magnesium sulfate, filtered and concentrated under reduced pressure to a white solid (C-benzofuran-5-yl-methylamine, 0.855 g, 54%).

References:

Cody, Wayne Livingston;Edmunds, Jeremy John;Holsworth, Daniel Dale;Powell, Noel Aaron US2004/204455, 2004, A1 Location in patent:Page/Page column 18

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References

23145-07-5 Synthesis

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References