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123566-33-6

(1-BENZYL-1H-IMIDAZOL-2-YL)-ACETIC ACID synthesis

2synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 24 percent / NEt3, / acetonitrile / 1.) 0 deg C, 2.) reflux, 18 h
2: 23 percent / H2 / 10percent Pd/C / ethanol / 2 h / 2585.7 Torr

References:

Kruse, Lawrence I.;Kaiser, Carl;DeWolf, Walter E.;Finkelstein, Joseph A.;Frazee, James S.;et al. [Journal of Medicinal Chemistry,1990,vol. 33,# 2,p. 781 - 789]