1-benzyl-2-methyl-1H-imidazole-carbaldehyde synthesis
- Product Name:1-benzyl-2-methyl-1H-imidazole-carbaldehyde
- CAS Number:39269-74-4
- Molecular formula:C12H12N2O
- Molecular Weight:200.24
100-39-0
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39269-74-4
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Yield:39269-74-4 99%
Reaction Conditions:
with potassium carbonate in DMF (N,N-dimethyl-formamide) at 0 - 20;
Steps:
12 Method 12; 1-Benzyl-5-formyl-2-methylimidazole
Benzyl bromide (21.4 ml, 0.18 mol) was added carefully to a mixture of 4-formyl-2-methylimidazole (18.1 g, 0.16 mol) and potassium carbonate (45.0 g, 0.33 mol) in DMF (100 ml) at 0° C. and the reaction mixture allowed to warm to ambient temperature. The mixture was then partitioned between EtOAc and saturated aqueous sodium hydrogen carbonate solution, the organic phase separated and dried. The volatiles were removed by evaporation to give the title compound as crude mixture of regioisomers 32.0 g, (99%). M/z: 201.
References:
US2004/14776,2004,A1 Location in patent:Page/Page column 32
100-46-9
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