1-BENZYL-3-HYDROXYMETHYLPIPERIDINE synthesis

5synthesis methods

Product Name:1-BENZYL-3-HYDROXYMETHYLPIPERIDINE
CAS Number:85387-44-6
Molecular formula:C13H19NO
Molecular Weight:205.3

72551-53-2 Synthesis

72551-53-2
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$8.00/5g

85387-44-6
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$60.00/100mg

Yield:85387-44-6 99%

Reaction Conditions:

Stage #1: ethyl 1-benzylpiperidine-3-carboxylatewith lithium aluminium tetrahydride in tetrahydrofuran at 5; for 1 h;
Stage #2: with ethyl acetate in tetrahydrofuran;

Steps:

A5

(l-Benzylpipeiidin-3-yl)methanol; To a solution of ethyl l-benzylpiperidine-3-carboxylate (1.0 g) in tetrahydrofuran (10 mL) at 5°C under argon was added a IM solution of lithium aluminium hydride (4.04 mL) dropwise. The mixture was stirred for 1 hour at 5°C and then quenched by the dropwise addition of ethyl acetate (5 mL). The mixture was warmed to room temperature and dichloromethane (150 mL) was added followed by saturated aqueous sodium potassium tartrate (50 mL). The mixture was stirred vigorously overnight. The layers were separated EPO and the organic layer was dried over magnesium sulfate and evaporated to give the title compound as a colourless oil (0.82 g, 99%).

References:

WO2006/67401,2006,A1 Location in patent:Page/Page column 190-191

4606-65-9 Synthesis