1-BENZYL-3-NITRO-1H-PYRAZOLE synthesis
- Product Name:1-BENZYL-3-NITRO-1H-PYRAZOLE
- CAS Number:898053-27-5
- Molecular formula:C10H9N3O2
- Molecular Weight:203.2
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Yield:898053-27-5 90%
Reaction Conditions:
with tetrabutylammomium bromide;sodium hydroxide in water;dimethyl sulfoxide at 20;
Steps:
8 Synthesis of 1-benzyl-3-nitro-1H-pyrazole
3-Nitropyrazole (11.3 g, 0.1 mol) at room temperature,Benzyl bromide (17.1 g, 0.1 mol), tetrabutylammonium bromide (1.6 g, 0.005 mol), dissolved in 10 ml of dimethyl sulfoxide (DMSO).Add sodium hydroxide solution [sodium hydroxide solution: 8.8 g (0.22 mol)The solution obtained by dissolving sodium hydroxide in 10 ml of water], the reaction is exothermic,After the dropwise addition is completed, the mixture is stirred at room temperature overnight, and diluted with water to quench.Extract with dichloromethane, dry, concentrate and recrystallize with semi-dry petroleum ether.The product was obtained in 18.3 g with a yield of 90%.
References:
CN108863936,2018,A Location in patent:Paragraph 0033; 0034
100-39-0
423 suppliers
$10.00/10g
898053-27-5
23 suppliers
inquiry
100-39-0
423 suppliers
$10.00/10g
26621-44-3
212 suppliers
$6.00/5g
898053-27-5
23 suppliers
inquiry
145162-69-2
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