ChemicalBook CAS DataBase List 1-BENZYL-4-(ETHOXYCARBONYLMETHYL)PIPERAZINE

1-BENZYL-4-(ETHOXYCARBONYLMETHYL)PIPERAZINE synthesis

4synthesis methods

Product Name:1-BENZYL-4-(ETHOXYCARBONYLMETHYL)PIPERAZINE
CAS Number:23173-76-4
Molecular formula:C15H22N2O2
Molecular Weight:262.35

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105-36-2 Synthesis

105-36-2
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1-BENZYL-4-(ETHOXYCARBONYLMETHYL)PIPERAZINE

23173-76-4
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$184.00/500mg

Yield:23173-76-4 100%

Reaction Conditions:

in benzene at 20; for 2 h;

Steps:

4.1 ethyl 4-benzylpiperazineacetate

4-Benzylpiperazine(3.3 ml, 18.9 mmol) was added to a solution of ethyl bromoacetate(1 ml, 9.0 mmol) in benzene(9 ml), which was then stirred for 2 hours at a room temperature, diluted with ethyl ether, and washed with saturated NaCl solution. The separated organic layer was dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 2.38 g of the titled compound. (Yield 100%). NMR(CDCl3): 1.3(t, 3H), 2.6(t, 8H), 3.2(s, 2H), 3.6(s, 2H), 4.2(q, 2H), 7.3(m, 5H).

References:

US6352993,2002,B1 Location in patent:Page column 13-14

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105-39-5 Synthesis