1-BENZYL-4-NITROSOPIPERAZINE synthesis
- Product Name:1-BENZYL-4-NITROSOPIPERAZINE
- CAS Number:40675-45-4
- Molecular formula:C11H15N3O
- Molecular Weight:205.26
2759-28-6
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40675-45-4
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Yield:40675-45-4 97.3%
Reaction Conditions:
with hydrogenchloride;sodium nitrite in water at 0 - 20;
Steps:
2.1 Step (1): 1-benzyl-4-nitrosopiperazine (XVI-1)
To the reaction flask was added compound XV-1 (50.0 g, 0.284 mol). A 2 M hydrochloric acid solution (160 mL, 0.318 mol) was added dropwise at about 0 ° C, and the resulting reaction solution was stirred at 0 ° C for 10 minutes, An aqueous solution of NaNO2 (NaNO2 (24.50 g, 0.335 mol) was added to water (58 mL)) was added and the temperature was maintained at 0 to 10 ° C for 40 minutes. The reaction was stirred at room temperature overnight. The next day, the reaction heated to 35 ° C for about 1 hour (a large number of insoluble solid generated), and then the reaction flask into the low temperature tank, 0 cooling and precipitation, and finally by filtration to separate the solid product. The aqueous layer was extracted with DCM and the organic phases were combined and dried over anhydrous magnesium sulfate. The desiccant was removed by suction filtration and the solvent was removed by rotary evaporation to give the solid product. And finally dried under reduced pressure oven at 50 ° C to give the compound of formula XVI-1 (56.71 g) as a pale yellow solid (yield 97.30%).
References:
CN106554318,2017,A Location in patent:Paragraph 0144; 0145; 0146; 0147
5632-47-3
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$105.00/100mg
100-39-0
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$10.00/10g
40675-45-4
17 suppliers
inquiry
100-39-0
425 suppliers
$10.00/10g
40675-45-4
17 suppliers
inquiry