1-Benzyl-6-tosyl-1,6-diazaspiro[3.3]heptan-3-ol synthesis

2synthesis methods

Product Name:1-Benzyl-6-tosyl-1,6-diazaspiro[3.3]heptan-3-ol
CAS Number:1349199-70-7
Molecular formula:C19H22N2O3S
Molecular Weight:358.45

1,6-Diazaspiro[3.3]heptan-2-one, 3-hydroxy-6-[(4-methylphenyl)sulfonyl]-1-(phenylmethyl)-

1349199-69-4
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1-Benzyl-6-tosyl-1,6-diazaspiro[3.3]heptan-3-ol

1349199-70-7
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$623.00/100mg

Yield:1349199-70-7 67%

Reaction Conditions:

Stage #1: 1-benzyl-3-hydroxy-6-tosyl-1,6-diazaspiro[3.3]heptan-2-onewith chlorohydroalane in tetrahydrofuran;diethyl ether at 60; for 1.66667 h;Inert atmosphere;
Stage #2: with water;sodium hydrogencarbonate in tetrahydrofuran;diethyl ether at 20;Inert atmosphere;

References:

Burkhard, Johannes A.;Guerot, Carine;Knust, Henner;Carreira, Erick M. [Organic Letters,2012,vol. 14,# 1,p. 66 - 69] Location in patent:supporting information; experimental part

6-[(4-Methylphenyl)sulfonyl]-1-benzyl-1,6-diazaspiro[3.3]heptan-2-one

1263296-91-8
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1349199-70-7
8 suppliers
$623.00/100mg

References