ChemicalBook CAS DataBase List 1-Benzylazetidin-3-ol

1-Benzylazetidin-3-ol synthesis

7synthesis methods

Product Name:1-Benzylazetidin-3-ol
CAS Number:54881-13-9
Molecular formula:C10H13NO
Molecular Weight:163.22

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54881-13-9
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Yield:54881-13-9 77%

Reaction Conditions:

with methanol;sodium methylate at 20; for 0.5 h;

Steps:

37
Preparation Example 37: l-benzyl-azetidine-3-oll-Benzyl-3-trimethylsilyloxy-azetidine (1.8 g, 7.65 mmol) prepared in Preparation Example 25 was dissolved in methanol (9 ml), sodium methoxide (826 mg, 15.29 mmol) was added thereto, and stirred at room temperature for 30 min. The solvent was removed by evaporation under a reduced pressure, and the residue was extracted using ethyl acetate. The organic extract layer was washed with water, dried over anhydrous magnesium sulfate, and concentrated under a reduced pressure, to obtain 0.964 g (yield: 77 %) of the title compound.*H NMR (200 MHz, CDC1₃): 8 2.95 (m, 2H), 3.61 (m, 4H), 4.42 (m, 1H), 7.27 (m, 5H).

References:

KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY WO2006/25634, 2006, A1 Location in patent:Page/Page column 19

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