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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 1-Benzylazetidin-3-ol
54881-13-9

1-Benzylazetidin-3-ol synthesis

7synthesis methods
5.0 g of l, 3.52 g of methanesulphonyl chloride and 6 ml of triethylamine in 40 ml of dichloromethane were stirred together for 18 hours. The mixture was filtered and the solvent was evaporated under reduced pressure. The residue was purified by chromatography on silica gel using isopropanol in dichloromethane as eluent to give the mesylate of 1-benzylazetidin-3-ol, yield 4.25 g.
1-BENZYL-3-(TRIMETHYLSILOXY)AZETIDINE

111043-42-6
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1-Benzylazetidin-3-ol

54881-13-9
189 suppliers
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-

Yield:54881-13-9 77%

Reaction Conditions:

with methanol;sodium methylate at 20; for 0.5 h;

Steps:

37
Preparation Example 37: l-benzyl-azetidine-3-oll-Benzyl-3-trimethylsilyloxy-azetidine (1.8 g, 7.65 mmol) prepared in Preparation Example 25 was dissolved in methanol (9 ml), sodium methoxide (826 mg, 15.29 mmol) was added thereto, and stirred at room temperature for 30 min. The solvent was removed by evaporation under a reduced pressure, and the residue was extracted using ethyl acetate. The organic extract layer was washed with water, dried over anhydrous magnesium sulfate, and concentrated under a reduced pressure, to obtain 0.964 g (yield: 77 %) of the title compound.*H NMR (200 MHz, CDC13): 8 2.95 (m, 2H), 3.61 (m, 4H), 4.42 (m, 1H), 7.27 (m, 5H).

References:

KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY WO2006/25634, 2006, A1 Location in patent:Page/Page column 19

FullText

75605-52-6 Synthesis
benzyl-(1-amino-3-chloro-2-propanol)

75605-52-6
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1-Benzylazetidin-3-ol

54881-13-9
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References
100-46-9 Synthesis
Benzylamine

100-46-9
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106-89-8 Synthesis
Epichlorohydrin

106-89-8
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1-Benzylazetidin-3-ol

54881-13-9
189 suppliers
$9.00/250mg

References
80236-09-5 Synthesis
2-Oxiranemethanamine, N-(phenylmethyl)-

80236-09-5
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1-Benzylazetidin-3-ol

54881-13-9
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$9.00/250mg

References
Benzenemethanamine, N-[3-chloro-2-[(trimethylsilyl)oxy]propyl]-

111043-32-4
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1-Benzylazetidin-3-ol

54881-13-9
189 suppliers
$9.00/250mg

References

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