ChemicalBook CAS DataBase List 1-(Benzyloxy)-2-methyl-3-nitrobenzene

1-(Benzyloxy)-2-methyl-3-nitrobenzene synthesis

6synthesis methods

Product Name:1-(Benzyloxy)-2-methyl-3-nitrobenzene
CAS Number:20876-37-3
Molecular formula:C14H13NO3
Molecular Weight:243.26

100-39-0
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$10.00/10 g

20876-37-3
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$9.00/250mg

Yield: 100%

Reaction Conditions:

Stage #1:3-nitro-o-cresol with potassium carbonate in N,N-dimethyl-formamide
Stage #2:benzyl bromide in N,N-dimethyl-formamide at 20; for 3 h;

Steps:

22
(Referential Example 22) Synthesis of 2-benzyloxy-6-nitrotoluene (referential compound 22-1) Potassium carbonate (41.5 g, 300 mmol) and 200 ml of N,N-dimethylformamide were added to 30.6 g (200 mmol) of 2-methyl-3-nitrophenol. After that, 23.8 ml (200 mmol) of benzyl bromide was added thereto with stirring in an argon stream and the mixture was stirred at room temperature for 3 hours. After the reaction was finished, the reaction solution was poured into 1,000 ml of water and and the mixture was extracted with 800 ml of toluene and 500 ml of the same for two times. The organic layer was successively washed with water and a saturated aqueous solution of sodium chloride, dried over anhydrous magnesium sulfate and concentrated in vacuo to give 49.3 g of the title compound as yellow powder (yield: quantitative). Rf value: 0.48 (n-hexane: ethyl acetate = 4:1 (v/v)) Mass spectrum (CI, m/z): 244 (M⁺ + 1) ¹H-NMR spectrum (CDCl₃, δ ppm): 2.42 (s, 3H), 5.13 (s, 2H), 7.08-7.11 (m, 1H), 7.21-7.27 (m, 1H), 7.32-7.44 (m, 6H)

References:

Ube Industries, Ltd.;SANTEN PHARMACEUTICAL CO., LTD. EP1679308, 2006, A1 Location in patent:Page/Page column 42

5460-31-1 Synthesis