1-(Benzyloxy)-4-bromo-2,3-difluorobenzene synthesis
- Product Name:1-(Benzyloxy)-4-bromo-2,3-difluorobenzene
- CAS Number:941294-52-6
- Molecular formula:C13H9BrF2O
- Molecular Weight:299.11
144292-32-0
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100-39-0
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941294-52-6
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Yield:941294-52-6 90.9%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 25; for 4 h;Inert atmosphere;
Steps:
48.1 Step 1 : l -(Benzyloxy)-4-bromo-2, -difluorobenzene
Under nitrogen, a solution of 4-bromo-2,3-difluorophenol (2.0 g, 9.57 mmol) and benzyl bromide (2.46 g, 14.35 mmol) in /V,/V-dimethylformamide (20 mL) was added potassium carbonate (3.96 g, 28.71 mmol), the resulting solution was stirred for 4 h at 25 °C. The resulting solution was diluted with water, extracted with ethyl acetate, washed with brine, dried over sodium sulfate and concentrated. The residue was purified by silica flash chromatography eluting with ethyl acetate/petroleum ether (20:80) to afford the title compound (2.74 g, 90.9% yield) as a white solid. LCMS (ESI): [M+H]+ = 299.0.
References:
WO2020/56089,2020,A1 Location in patent:Paragraph 0489
6418-38-8
328 suppliers
$10.00/1g
941294-52-6
27 suppliers
$41.00/1g