![](/CAS/GIF/259808-67-8.gif)
1-Boc-3,3-dimethylpiperazine synthesis
- Product Name:1-Boc-3,3-dimethylpiperazine
- CAS Number:259808-67-8
- Molecular formula:C11H22N2O2
- Molecular Weight:214.3
![Di-tert-butyl dicarbonate](/CAS/GIF/24424-99-5.gif)
24424-99-5
821 suppliers
$13.50/25G
![2,2-DIMETHYL-PIPERAZINE](/CAS/GIF/84477-72-5.gif)
84477-72-5
147 suppliers
$13.00/100mg
![1-Boc-3,3-dimethylpiperazine](/CAS/GIF/259808-67-8.gif)
259808-67-8
109 suppliers
$15.00/100mg
Yield: 96%
Reaction Conditions:
in dichloromethane at 0 - 20; for 4 h;
Steps:
4.C
To a solution of 2,2-dimethylpiperazine (400 mg) in dichloromethane (20 mL) at 0° C. was added di-tert-butyl dicarbonate (766 mg). The reaction was stirred at room temperature for 4 h and then quenched with water (20 mL) and extracted into dichloromethane (2*40 mL). The combined organics were washed with saturated aqueous brine solution (40 mL), dried (MgSO4) and concentrated to give 3,3-diemethyl-piperazine-1-carboxylic acid tert-butyl ester as a white solid (720 mg, 96%).
References:
Piramed Limited;Genentech, Inc. US2008/76758, 2008, A1 Location in patent:Page/Page column 90
![2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile](/CAS/GIF/58632-95-4.gif)
58632-95-4
271 suppliers
$7.00/5g
![2,2-DIMETHYL-PIPERAZINE](/CAS/GIF/84477-72-5.gif)
84477-72-5
147 suppliers
$13.00/100mg
![1-Boc-3,3-dimethylpiperazine](/CAS/GIF/259808-67-8.gif)
259808-67-8
109 suppliers
$15.00/100mg