ChemicalBook CAS DataBase List 1-Boc-4-(2-chloro-4-nitrophenyl)piperazine

1-Boc-4-(2-chloro-4-nitrophenyl)piperazine synthesis

5synthesis methods

Product Name:1-Boc-4-(2-chloro-4-nitrophenyl)piperazine
CAS Number:193902-80-6
Molecular formula:C15H20ClN3O4
Molecular Weight:341.79

24424-99-5 Synthesis

24424-99-5
821 suppliers
$13.50/25G

114878-60-3
96 suppliers
$12.00/250mg

1-Boc-4-(2-chloro-4-nitrophenyl)piperazine

193902-80-6
13 suppliers
$24.05/250mg

Yield:193902-80-6 86%

Reaction Conditions:

with dmap;triethylamine in dichloromethane at 20;

Steps:

7

According to Scheme 5 Step 1 : A solution of l-(2-chloro-4-nitrophenyl)piperazine (2.90 mmol, 700 mg), BoC₂O (3.19 mmol, 0.96 mL), Et₃N (3.48 mmol, 0.49 mL) and of DMAP (0.29 mmol, 35 mg) in DCM (5 mL) was stirred at room temperature overnight. The organic phase was washed once with HCl 0.1 M, once with water, once with brine, was dried over Na₂SO₄, was filtered and was concentrated under reduced pressure to afford tert-butyl 4-(2-chloro-4-nitrophenyl)piperazine-l-carboxylate (2.50 mmol, 854 mg, 86%). The product was used without further purification. LC (Zorbax SB-Ci₈, 3.5μm, 4.6x30mm Column): RT = 3.19 min; MS m/z ES⁺= 342.

References:

WO2009/10454,2009,A2 Location in patent:Page/Page column 36

350-30-1 Synthesis