1-BOC-4-(3,4-DICHLOROPHENYL)-4-HYDROXYPIPERIDINE synthesis
- Product Name:1-BOC-4-(3,4-DICHLOROPHENYL)-4-HYDROXYPIPERIDINE
- CAS Number:256958-81-3
- Molecular formula:C16H21Cl2NO3
- Molecular Weight:346.25
Yield:256958-81-3 73.4%
Reaction Conditions:
Stage #1: 4-bromo-1,2-dichlorobenzenewith n-butyllithium in tetrahydrofuran at -78; for 0.5 h;
Stage #2: N-tert-butyloxycarbonylpiperidin-4-one in tetrahydrofuran at -78; for 2 h;
References:
Fyfe, Tim J.;Kellam, Barrie;Sykes, David A.;Capuano, Ben;Scammells, Peter J.;Lane, J. Robert;Charlton, Steven J.;Mistry, Shailesh N. [Journal of Medicinal Chemistry,2019,vol. 62,# 21,p. 9488 - 9520]
79175-35-2
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79099-07-3
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256958-81-3
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