1-BOC-4-CYANO-4-(2-FLUOROPHENYL)-PIPERIDINE synthesis
2synthesis methods
- Product Name:1-BOC-4-CYANO-4-(2-FLUOROPHENYL)-PIPERIDINE
- CAS Number:726198-18-1
- Molecular formula:C17H21FN2O2
- Molecular Weight:304.36
Yield:726198-18-1 78%
Reaction Conditions:
Stage #1: tert-butyl 4-(2-fluorophenyl)-4-(hydroxymethyl)piperidine-1-carboxylatewith methanesulfonyl chloride;triethylamine in dichloromethane;
Stage #2: sodium cyanide in dimethyl sulfoxide at 100; for 18 h;
References:
Bandarage, Upul K.;Davies, Robert J. [Tetrahedron Letters,2011,vol. 52,# 3,p. 469 - 469] Location in patent:scheme or table
