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1-BOC-4-CYANO-4-(3,4-DIFLUOROPHENYL)-PIPERIDINE synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1.1: Bu4N(1+)*HSO4(1-) / aq. NaOH
2.1: 1-chloroethylchloroformate / 1,2-dichloro-ethane / 85 °C
2.2: aq. NaOH / methanol

References:

Liu, Jian;Jian, Tianying;Sebhat, Iyassu;Nargund, Ravi [Tetrahedron Letters,2006,vol. 47,# 29,p. 5115 - 5117]